Endocrine Abstracts

Introduction: The syndrome of reduced sensitivity to thyroid hormone (SRSTH) due to mutations of thyroid hormone receptor β (TRB) consists of an inappropriate secretion of TSH with elevated levels of thyroid hormones. Cardiovascular manifestations are often the ones that affect patients. Our aim was to evaluate the cardiac and vascular characteristics of patients with SRSTH due to TRB mutations.Materials and methods: We analysed cl...

Metabolic diseases (type 2 diabetes (T2D) and obesity) prevalence is increasing in the world. This is partly related to a change in lifestyle with an increase of caloric intake and a decrease of physical activity. Environmental causes are also involved among them exposure to bisphenol A (BPA). The mode of action of the latter is unknown. Beyond a suggesting effect relayed by nuclear receptors, we propose that BPA can act by modulating the functionality of G protein-coupled rec...

Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is one of the most frequent endocrine genetic diseases. Adrenal rests have been described and can decrease fertility in men1. In a retrospective multi-center study we wanted 1.to evaluate the frequency of adrenal rests in classical forms of CAH (21-OH deficiency) by systematic ultrasonography (US); 2.to try to find the cause of this abnormality looking for a relationship between genotype and pheno...